Past Webinar – Technological Advancements in Functional Assessments and Fall Prevention, John Ralston and Hamed Tabkhi

https://www.youtube.com/watch?v=37KcJYSMRHE Overview: This webinar gives an overview of two of the MassAITC pilot projects.  John Ralston, from Neursantys describes their work on bioelectronic restoration of the body’s aging balance system.  In addition, Hamed Tabkhi of ForesightCares discusses their product, AVA, which is an AI-powered, video-based mobile app designed to enable clinically grounded fall risk assessments directly in the home. Abstracts: Wearable diagnostic sensors and personalized bioelectronic therapeutics for the treatment of neurophysiological conditions Bioelectronics has been an important component of modern medicine for more than half a century, because of the ability to provide functional recovery for conditions with limited pharmaceutical treatment options. Bioelectronic devices have now received regulatory approval for a growing range of medical conditions and have been shown to provide effective treatment for a growing range of neurological conditions.In this talk we will review the…

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Publication: Causal Directed Acyclic Graph-informed Reward Design

Authors: Luton Zou, Ziping Xu, Daiqi Gao, Susan Murphy Abstract It is well known that in reinforcement learning (RL) different reward functions may lead to the same optimal policy, while some reward functions can be substantially easier to learn. In this paper, we propose a framework for reward design by constructing surrogate rewards with mediators informed by causal directed acyclic graphs (DAGs), which are often available in real-world applications through domain knowledge. We show that under the surrogacy assumption, the proposed reward is unbiased and has lower variance than the primary reward. Specifically, we use an online reward design agent that adaptively learns the target surrogate reward in an unknown environment. Feeding the surrogate rewards to standard online learning oracles, we show that the regret bound can be improved. Our framework provides a theoretical improvement…

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Strategic Partnership: Synseer Partners with MindMics to Deliver Real-Time Heart Health Insights Through Everyday In-ear Devices

CAMBRIDGE, MA – May 29, 2025 — synseer, a leader in personalized health optimization, has announced a strategic collaboration with MindMics, the pioneer of in-ear infrasonic hemodynography (IH). Through this partnership, Synseer will integrate the MindMics Heart Health Platform into its intelligent wellness ecosystem—bringing real-time heart health insights directly to its users. “The integration of MindMics’ Heart Health Platform is a powerful addition to synseer’s mission of enabling real-time, data-driven wellness,” said John Martino II, CEO of synseer. “Our users will now have access to high-fidelity health data that was previously only available in clinical environments—empowering smarter decisions, every day.” MindMics’ patented technology captures low-frequency acoustic biosignals from within the ear canal, enabling non-invasive tracking of vital heart health metrics—including heart rate, heart rate variability, and physiological states related to stress and recovery. These clinically…

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Publication: Digital Twins for Just-in-Time Adaptive Interventions (JITAI-Twins): A Framework for Optimizing and Continually Improving JITAIs

Authors: Asim H. Gazi, Daiqi Gao, Susobhan Ghosh, Ziping Xu, Anna Trella, Predrag Klasnja, Susan A. Murphy Abstract Just-in-time adaptive interventions (JITAIs) are nascent precision medicine systems that extend personalized healthcare support to everyday life. A challenge in designing JITAIs is that personalized support often involves sophisticated decision-making algorithms. These decision-making algorithms can require numerous non-trivial design decisions that must be made between successive JITAI deployments (e.g., hyperparameter selection for an artificial intelligence algorithm). Making design decisions between deployments–rather than during deployment–ensures intervention fidelity and enhances the ability to replicate results. Yet, each deployment can be costly, precluding the use of A/B testing for every design decision. How should design decisions be made strategically between JITAI deployments? This paper introduces digital twins for just-in-time adaptive interventions (JITAI-Twins) to address this question. JITAI-Twins are “digital twins…

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Past Webinar – The Impact of Light Exposure on Sleep: A Pilot Study, Erik Page (Blue Iris Labs)

https://www.youtube.com/watch?v=BcBlsqpNYeg Abstract: Light exposure is the primary regulator of human circadian rhythms, influencing many aspects of our physiology and behavior, including sleep, alertness, and mood, as well as many neuroendocrine and cognitive functions. While we have evolved experiencing “bright days and dark nights,” most of us now experience significantly darker days and brighter nights than our pre-modern ancestors, likely resulting in widespread circadian disruption. And as we age, the relationship between light exposure, circadian rhythms, and sleep can be further compromised both through normal aging (e.g., less light reaching the retina due to clouding of the lens) and age-related risk factors, such as Alzheimer’s Disease (AD), which is known to damage the brain’s master clock. This webinar will review the current science related to light exposure, circadian rhythms, and sleep, looking at aging and AD…

Continue ReadingPast Webinar – The Impact of Light Exposure on Sleep: A Pilot Study, Erik Page (Blue Iris Labs)

Grant Funding: R41 AG092119

Continuation of VR technology development focused on the caregiver side of the dyad. Public Health Relevance Statement: The VR-CARES project is an innovative, collaborative effort that invites home health dementia caregivers into the design process of a virtual reality platform seeking to mitigate their work-related burden and social isolation by cultivating a virtual community of support. The co-created, caregiver-specific VR platform will serve as a safe, communal space where caregivers can remotely connect with their peers, share fun experiences together, access support, learn self-care and build resilience within a supportive virtual network to enhance their social and mental health and job satisfaction. Central to VR-CARES is the principle of user-led innovation, ensuring that the technology not only serves but is informed and successfully adopted by the very individuals it intends to benefit, an important standard…

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Publication: Returning Individualized Wearable Sensor Results to Older Adult Research Participants: A Pilot Study

Authors: Shelby L Bachman, Krista S Leonard-Corzo, Jennifer M Blankenship, Michael A Busa, Corinna Serviente, Matthew W Limoges, Robert T Marcotte, Ieuan Clay, Kate Lyden Abstract Background: Wearable sensors that monitor physical behaviors are increasingly adopted in clinical research. Older adult research participants have expressed interest in tracking and receiving feedback on their physical behaviors. Simultaneously, researchers and clinical trial sponsors are interested in returning results to participants, but the question of how to return individual study results derived from research-grade wearable sensors remains unanswered. In this study, we (1) assessed the feasibility of returning individual physical behavior results to older adult research participants and (2) obtained participant feedback on the returned results. Methods: Older adult participants (N = 20; ages 67-96) underwent 14 days of remote monitoring with 2 wearable sensors. We then used a semiautomated…

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