News & Events

Registration: https://tinyurl.com/MassAITC-November2026-webinar Abstract: Ambient generative AI scribes are spreading across U.S. health systems faster than evidence about their effects can be generated. A recent meta-analysis found that only 0.4% of studies of AI in medicine were real-world randomized trials, and the stakes of that gap are highest for older adults, who carry the greatest burdens of multimorbidity, polypharmacy, and cognitive impairment and are the most exposed to any change in how clinicians diagnose, prescribe, and communicate.  This webinar opens with a brief introduction to APEX-ADRD (Accelerating Platforms for Evaluating and eXecuting AI Lifecycles in Alzheimer's Disease and Related Dementias), an NIA-funded AI and Technology Collaboratory based at UCLA that serves investigators and technology developers nationwide and supports pilot projects across the full AI lifecycle, from AI-ready data and model development to pragmatic trials and post-deployment…

Abstract: Identifying drugs that slow biological aging in humans is a central goal of geroscience, but a key confounder in observational studies is that drugs prescribed for serious conditions may lower biological age scores indirectly by reducing disease burden rather than by exerting a direct geroprotective effect. To address this, we developed an analytical framework that incorporates indication-specific covariates, isolating drug-associated changes in biological age that are independent of disease modification. Applying this approach across large data resources, we systematically evaluate approved medications for geroprotective activity, and further interrogate top candidates using high-dimensional plasma proteomics and metabolomics to gain mechanistic insight into how these drugs alter aging trajectories. This framework provides a scalable strategy for identifying approved, commonly prescribed drugs with geroprotective properties, with broad implications for translating aging biology into actionable clinical interventions. Biography:…