News & Events

Oral Presentation: Best Practices for Digital Phenotyping Research in Aging Populations

This is part of the monthly MassAITC webinar series. Abstract: Digital phenotyping is transforming aging research by enabling high-frequency, real-world measurement of cognition, behavior, symptoms, and context through smartphones, wearables, and passive sensing technologies. This talk will review how digital health tools can complement traditional clinic-based assessments by capturing intraindividual variability, diurnal patterns, environmental influences, and subtle changes in cognitive and functional performance that may signal risk for neurodegenerative disease. Using examples from studies of healthy aging, MCI, Alzheimer’s disease risk, dementia caregiving, and related clinical populations, the talk will highlight best practices for designing digital phenotyping protocols, balancing participant burden with data richness, maximizing adherence, integrating active cognitive assessments with passive data streams and biomarkers, and applying analytic approaches that distinguish within-person change from between-person differences. The session will emphasize opportunities for digital phenotyping…

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Oral Presentation: Geroprotectors Hiding in Plain Sight: Systematic Identification of Approved Drugs that Reduce Organ-Specific Biological Age

Invited Speaker at the 2026 Systems Aging Gordon Research Conference titled: Complexities of Aging Across Species, Evolution, Reproduction, Human Longevity and Frailty Source: https://www.grc.org/systems-aging-conference/2026/

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Publication: Measuring multi-site pulse transit time with an AI-enabled mmWave radar

Authors: Jiangyifei Zhu, Kuang Yuan, Akrash Prabhakara, Yunzhi Li, Gongwei Wang, Kelly Michaelsen, Justin Chan & Swarun Kumar Abstract Pulse Transit Time (PTT) is a measure of arterial stiffness and a physiological marker associated with cardiovascular function, with an inverse relationship to diastolic blood pressure (DBP). We present an AI-enabled mmWave system for contactless multi-site PTT measurement using a single radar. By leveraging radar beamforming and deep learning algorithms our system simultaneously measures PTT and estimates diastolic blood pressure at multiple sites. The system was evaluated across three physiological pathways – heart-to-radial artery, heart-to-carotid artery, and mastoid area-to-radial artery – achieving correlation coefficients of 0.75–0.86 compared to contact-based reference sensors for measuring PTT. Furthermore, the system demonstrated correlation coefficients of 0.90–0.91 for estimating DBP, and achieved a mean error of -0.62–0.06 mmHg and standard deviation…

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Oral Presentation: Developing Agentic AI Chatbot Tools with Older Adults and Caregivers to Encourage Participation in ADRD Clinical Trials

This is part of the monthly MassAITC webinar series. Abstract: Hype around the potential of generative AI tools to transform healthcare is at an all time high, but their design and utility is often not user or patient-centered. This is particularly true for generalized large language models that have limited UI/UX features, may hallucinate or give incorrect medical/healthcare advice, or may lack conversational clarity and specificity. In fact, these tools are rarely designed in partnership with the end-user or patients they intend to serve. As part of a2 Collective Pilot award in partnership with MassAITC, S-3 Research and California State Fullerton have been developing “TRIALCHAT”, a multiagentic AI tool with the goal of navigating older adults and their caregivers to resources related to Alzheimer’s Disease and clinical research participation opportunities. Lessons learned from a technology…

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Past Webinar – Best Practices for Digital Phenotyping Research in Aging Populations

https://www.youtube.com/watch?v=nxRdD0OHu1c Abstract: Digital phenotyping is transforming aging research by enabling high-frequency, real-world measurement of cognition, behavior, symptoms, and context through smartphones, wearables, and passive sensing technologies. This talk will review how digital health tools can complement traditional clinic-based assessments by capturing intraindividual variability, diurnal patterns, environmental influences, and subtle changes in cognitive and functional performance that may signal risk for neurodegenerative disease. Using examples from studies of healthy aging, MCI, Alzheimer’s disease risk, dementia caregiving, and related clinical populations, the talk will highlight best practices for designing digital phenotyping protocols, balancing participant burden with data richness, maximizing adherence, integrating active cognitive assessments with passive data streams and biomarkers, and applying analytic approaches that distinguish within-person change from between-person differences. The session will emphasize opportunities for digital phenotyping to improve early detection, clinical trial endpoints, remote…

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