- Neuroimmune Foundation Models for Uncovering Biomarkers in Alzheimer’s Disease and Related Dementias
Mariano I. Gabitto, Allen Institute This project seeks to develop and train a novel machine learning foundational model that unifies brain and peripheral immune system omics data to identify blood biomarkers and map cellular changes in AD/ADRD.
- AI-Driven Earpiece Wearable to Enhance Symptom Management, Self-Care, and Caregiver Support in AD/ADRD Patients
Selina Zhu, Lumia Health. Paolo Bonato, Spaulding Rehabilitation Hospital) This pilot will test the Lumia ear wearable in people with Alzheimer’s disease and related dementias (AD/ADRD), allowing users to track blood flow to the head and report symptoms through a voice-controlled AI assistant. The study will focus on usability and adapting Lumia’s technology for older adults with cognitive impairments.
- Contactless Cardiovascular Health Monitoring for AD using an AI-Enhanced mmWave Radar
Justin Chan, Carnegie Mellon University. Swarun Kumar, Carnegie Mellon University. Neelesh Nadkarni, University of Pittsburgh. The proposed work uniquely aims to measure pulse transit time and blood pressure across different arterial points across the body using the reflections of wireless signals from a single AI-enabled mmWave radar device, which is a key enabler towards whole-body blood flow monitoring both in home and clinical environments.
- Scalable LLM Facilitation for Peer-to-Peer Support Groups of Informal Caregivers
Gregory Stock, Socratic Sciences Inc. Hamed Zamani, University of Massachusetts. Mary Mittleman, New York University. Socratic Sciences, in collaboration with UMass and NYU, is developing an AI-facilitated, question-driven app to help family caregivers of those with AD/ADRD connect and support one another in small, trusted groups around open-ended questions. The project will test and refine a group-facilitation AI bot to make meaningful peer support scalable, accessible, and affordable for millions of overwhelmed caregivers.
- Low-Cost mHealth Technology for Objectively Assessing Hearing Loss at Home
Wenyao Xu, Auspex Medix. Wei Sun, University at Buffalo. This project is to investigate an AI-powered, smartphone-based hearing screening tool that uses non-volitional pupillary responses to objectively assess hearing functions and loss.
- Empowering Caregivers of Individuals with Cognitive Impairment to Make Safe Nonprescription Drug Decisions
Eun Kyoung Choe, University of Maryland-College Park This pilot develops Aidara, an AI-powered digital health system that helps caregivers of individuals with cognitive impairments make safer over-the-counter medication decisions. Through multimodal interaction and personalized guidance, Aidara aims to support informed decision-making and reduce medication-related risks.
- AI-Driven Drug Repurposing to Identify Potential Geroprotectors
Jesse Poganik, Brigham and Women’s Hospital This pilot project leverages artificial intelligence and advanced aging biomarkers to identify existing FDA-approved medications that may slow biological aging, using clinical data and biospecimens from over 155,000 participants in the Mass General Brigham Biobank. By focusing on approved drugs with established safety profiles, this approach enables rapid translation of findings into clinical practice for promoting healthy aging and preventing age-related diseases.
- Voiceitt: AI-Enabled Speech Recognition for Older Adults with Severe Dysarthria
Katie Seaver, The Babel Group. Rachel Khasky-Levy, The Babel Group. This project will evaluate a personalized speech recognition app built by Voiceitt for adults aged 55+ with severe dysarthria, focusing on accuracy, usability, and user satisfaction. Participants will train the app on their own speech and use it in daily life, with support from The Babel Group.
- Wearable Heart Failure Socks for Exacerbation and Treatment Monitoring
Pamela Z. Cacchione, University of Pennsylvania. Li Shen, University of Pennsylvania. Heart Failure Monitoring Socks will be used in hospitalized persons with heart failure to gather data on heart failure exacerbations and responses to treatment. We will use this data to develop predictive models for edema and fatigue due to heart failure.
Mariano I. Gabitto, Allen Institute This project seeks to develop and train a novel machine learning foundational model that unifies brain and peripheral immune system omics data to identify blood biomarkers and map cellular changes in AD/ADRD.
Selina Zhu, Lumia Health. Paolo Bonato, Spaulding Rehabilitation Hospital) This pilot will test the Lumia ear wearable in people with Alzheimer’s disease and related dementias (AD/ADRD), allowing users to track blood flow to the head and report symptoms through a voice-controlled AI assistant. The study will focus on usability and adapting Lumia’s technology for older adults with cognitive impairments.
Justin Chan, Carnegie Mellon University. Swarun Kumar, Carnegie Mellon University. Neelesh Nadkarni, University of Pittsburgh. The proposed work uniquely aims to measure pulse transit time and blood pressure across different arterial points across the body using the reflections of wireless signals from a single AI-enabled mmWave radar device, which is a key enabler towards whole-body blood flow monitoring both in home and clinical environments.
Gregory Stock, Socratic Sciences Inc. Hamed Zamani, University of Massachusetts. Mary Mittleman, New York University. Socratic Sciences, in collaboration with UMass and NYU, is developing an AI-facilitated, question-driven app to help family caregivers of those with AD/ADRD connect and support one another in small, trusted groups around open-ended questions. The project will test and refine a group-facilitation AI bot to make meaningful peer support scalable, accessible, and affordable for millions of overwhelmed caregivers.
Wenyao Xu, Auspex Medix. Wei Sun, University at Buffalo. This project is to investigate an AI-powered, smartphone-based hearing screening tool that uses non-volitional pupillary responses to objectively assess hearing functions and loss.
Eun Kyoung Choe, University of Maryland-College Park This pilot develops Aidara, an AI-powered digital health system that helps caregivers of individuals with cognitive impairments make safer over-the-counter medication decisions. Through multimodal interaction and personalized guidance, Aidara aims to support informed decision-making and reduce medication-related risks.
Jesse Poganik, Brigham and Women’s Hospital This pilot project leverages artificial intelligence and advanced aging biomarkers to identify existing FDA-approved medications that may slow biological aging, using clinical data and biospecimens from over 155,000 participants in the Mass General Brigham Biobank. By focusing on approved drugs with established safety profiles, this approach enables rapid translation of findings into clinical practice for promoting healthy aging and preventing age-related diseases.
Katie Seaver, The Babel Group. Rachel Khasky-Levy, The Babel Group. This project will evaluate a personalized speech recognition app built by Voiceitt for adults aged 55+ with severe dysarthria, focusing on accuracy, usability, and user satisfaction. Participants will train the app on their own speech and use it in daily life, with support from The Babel Group.