Publication: Predicting Orthostatic Symptoms Using a Multiparameter Wearable Sensor

Authors: Ziad A Elhajjaji, Amar S Basu Abstract Orthostatic disorders affect 30% of older adults and increase the risk for falls. The current diagnostic standard, the blood pressure cuff, cannot capture the rapid, multifaceted dynamics of orthostasis physiology, resulting in frequent underdiagnosis. This paper demonstrates multiparameter, real-time measurement of orthostasis using TRACE, an earlobe mounted wearable developed in our group. In prior work, we demonstrated a novel metric called orthostatic hypovolemia (OHV1), the initial loss in cephalic (head) blood volume immediately upon standing. This study significantly advances our prior work by introducing an additional 2 metrics: OHV2, the cephalic blood volume deficit after the body achieves homeostasis after standing; and postural orthostatic tachycardia (POT), the increase in heart rate. The 3 metrics were evaluated in 101 older adults who wore the TRACE device during postural…

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Publication: Oscillometric blood pressure measurements on smartphones using vibrometric force estimation

Authors: Colin Barry, Yinan Xuan, Ava Fascetti, Alison Moore, Edward J Wang Abstract This paper proposes a smartphone-based method for measuring Blood Pressure (BP) using the oscillometric method. For oscillometry, it is necessary to measure (1) the pressure applied to the artery and (2) the local blood volume change. This is accomplished by performing an oscillometric measurement at the finger's digital artery, whereby a user presses down on the phone's camera with steadily increasing force. The camera is used to capture the blood volume change using photoplethysmography. We devised a novel method for measuring the force applied of the finger without the use of specialized smartphone hardware with a technique called Vibrometric Force Estimation (VFE). The fundamental concept of VFE relies on a phenomenon where a vibrating object is dampened when an external force is…

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Publication: Development of a One Dollar Blood Pressure Monitor

Authors: Yinan Xuan, Ava J. Fascetti, Colin Barry, Edward J. Wang Abstract BPClip is an ultra-low-cost cuffless blood pressure monitor. As a universal smartphone attachment, BPClip leverages the computational imaging power of smartphones to perform oscillometry based blood pressure measurements. This paper examines different design considerations in BPClip's development. The cost and accuracy of blood pressure measurements are the central design goals. Both requirements are achieved with the initial prototype that achieves a 0.80 USD material cost and a mean absolute error of 8.72 and 5.49 mmHg for systolic and diastolic blood pressure, respectively. Since a main motivator to develop BPClip is making blood pressure monitoring more accessible, usability is also central to the design. User studies were conducted throughout the design process to inform the most intuitive and accessible design features. In this paper,…

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Publication: ACM 2024 Conference Proceeds – Development of a One Dollar Blood Pressure Monitor

Authors: Yinan Xuan, Ava J. Fascetti, Colin Barry, Edward J. Wang Abstract BPClip is an ultra-low-cost cuffless blood pressure monitor. As a universal smartphone attachment, BPClip leverages the computational imaging power of smartphones to perform oscillometry based blood pressure measurements. This paper examines different design considerations in BPClip's development. The cost and accuracy of blood pressure measurements are the central design goals. Both requirements are achieved with the initial prototype that achieves a 0.80 USD material cost and a mean absolute error of 8.72 and 5.49 mmHg for systolic and diastolic blood pressure, respectively. Since a main motivator to develop BPClip is making blood pressure monitoring more accessible, usability is also central to the design. User studies were conducted throughout the design process to inform the most intuitive and accessible design features. In this paper,…

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Publication: Data-driven discovery of movement-linked heterogeneity in neurodegenerative diseases. Nature Machine Intelligence

Authors: Mark Endo, Favour Nerrise, Qingyu Zhao, Edith V Sullivan, Li Fei-Fei, Victor W Henderson, Kilian M Pohl, Kathleen L Poston, Ehsan Adeli Abstract Neurodegenerative diseases manifest different motor and cognitive signs and symptoms that are highly heterogeneous. Parsing these heterogeneities may lead to an improved understanding of underlying disease mechanisms; however current methods are dependent on clinical assessments and somewhat arbitrary choice of behavioral tests. Herein, we present a data-driven subtyping approach using video-captured human motion and brain functional connectivity (FC) from resting-state (rs)-fMRI. We applied our framework to a cohort of individuals at different stages of Parkinson's disease (PD). The process mapped the data to low-dimensional measures by projecting them onto a canonical correlation space that identified three PD subtypes: Subtype I was characterized by motor difficulties and poor visuospatial abilities; Subtype II exhibited difficulties in non-motor…

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Publication: Assessing Novel Orthostatic Vital Signs with a Wearable Sensor

Authors: Ziad A. Elhajjaji, Amar S. Basu Abstract Orthostatic hypotension (OH) is a reduction in blood pressure and cerebral blood flow upon standing. Presenting in nearly 30% of older adults, OH is associated with increased fall risk and other co-morbidities. The clinical standard for monitoring OH, a blood pressure (BP) cuff, fails to capture initial orthostatic hypotension (IOH) and rapid hemodynamic changes during orthostasis. In contrast, cerebral blood flow velocity (CBFV) and continuous BP requires costly instrumentation unsuitable for home monitoring. As result OH is often underdiagnosed and poorly managed. This paper proposes a novel method for monitoring OH using TRACE, a wireless earlobe sensor that quantifies orthostatic hypovolemia (OHV), postural orthostatic tachycardia (POT), and motion during a standup test. To our knowledge, OHV is a novel biometric that may be correlated with dizziness upon…

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Publication: Development of a One Dollar Blood Pressure Monitor

Authors: Yinan Xuan, Ava J. Fascetti, Colin Barry, Edward J. Wang Abstract BPClip is an ultra-low-cost cuffless blood pressure monitor. As a universal smartphone attachment, BPClip leverages the computational imaging power of smartphones to perform oscillometry based blood pressure measurements. This paper examines different design considerations in BPClip's development. The cost and accuracy of blood pressure measurements are the central design goals. Both of these requirements are achieved with the initial prototype that achieves a $0.80 USD material cost and a mean absolute error of 8.72 and 5.49 mmHg for systolic and diastolic blood pressure, respectively. Since a main motivator to develop BPClip is making blood pressure monitoring more accessible, usability is also central to the design. User studies were conducted throughout the design process to inform the most intuitive and accessible design features. In…

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