Leveraging AI for Just-in-Time Smartphone Solutions for Family Caregivers

Felipe A. Jain, Massachusetts General Hospital, Finale Doshi-Velez, Harvard University. Family caregivers of people living with dementia have high needs for skills training and methods to reduce stress. This project will study the feasibility of a just-in-time adaptive intervention delivered by smartphone to increase engagement and helpfulness of caregiver skills and relaxation content for caregivers.

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TRIALCHAT: Leveraging LLMs to enhance AD/ADRD clinical trial participation

Tim K. Mackey, S-3 Research LLC, Joshua Yang, California State University, Fullerton. This project will aim to develop TrialChat, an AI-powered chatbot and clinical trial navigator designed to increase participation in Alzheimer’s disease and related dementias (ADRD) clinical trials by providing tailored education, personalized trial matching, and recruitment support for older adults and caregivers.

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Using AI to Repurpose Small Molecules to Target Amyloid-tau Interactions in AD

Jeremy Linsley, Operant BioPharma This project will use a proprietary robotics and artificial intelligence to identify targets and clinically-tested drugs that could be repurposed for Alzheimer's disease by blocking the harmful interaction between Tau and Amyloid Precursor proteins.

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Protecting Patients against Phishing Attacks using AI-enabled Agents

Gang Wang, University of Illinois at Urbana-Champaign. Roopa Foulger, OSF. This project will design, prototype, evaluate, and potentially deploy an AI-enabled voice agent to assist patients (especially older adults) to better recognize phishing messages and reduce cybersecurity risks during patient outreach and communications.

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An AI-powered Digital Therapy Assistant for Monitoring and Treating Cognitive Impairment

Jennifer Flexman, Moneta Health. Michael Busa, UMass Amherst. This project will develop AI algorithms used by Moneta™ digital therapy assistant to monitor the speech of individuals with mild cognitive impairment and early dementia during cognitive rehabilitation therapy.

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Intelligent Cognitive Assistant for the Individuals with AD/ADRD for Handling Word-finding Difficulty

Archna Bhatia, Institute for Human & Machine Cognition, George Sperling, UCI. This project aims to develop an Intelligent Cognitive Assistant that provides real-time word retrieval support as well as personalized training to enhance word retrieval for individuals with mild cognitive impairment and Alzheimer’s Disease and Related Dementias.

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