
Investigators:
John Ralston, Neursantys Inc.
VP Nguyen, UMass Amherst
MassAITC Cohort: Year 3 (Aging)
Neursantys’ NEURVESTA wearable bioelectronic solution is a cutting-edge platform that integrates both diagnostic sensing and therapeutic treatment for degraded sensory and motor balance functions. This project will develop ML-driven methods to adapt the treatment to each patient’s unique sensory and motor impairment profile to increase the effectiveness of NEURVESTA’s current treatment protocol.
The NEURVESTA treatment protocol includes both a pre- and post-treatment diagnostic assessment using a novel neurophysiological impairment sensing technology called physiological vibration acceleration (phybrata) that quantifies each patient’s unique balance impairment profile. The subsequent therapeutic treatment utilizes a specialized form of non-invasive transcranial electric stimulation developed by Neursantys, called sub-threshold wideband stochastic Electrical Vestibular Stimulation (swsEVS), that has been shown to induce persistent neuroplastic recovery of degraded balance in patients between 55 and 90 years of age. The current NEURVESTA platform utilizes the same fixed swsEVS parameters for all patients, and treatment consists of three 20-minute sessions per week over a 6-week period.
By harnessing a retrospective data set comprised of over 2000 pre- and post-treatment phybrata measurements and unique balance maps, we will develop advanced ML algorithms to generate adaptive adjustments of swsEVS stimulation parameters that will further enhance therapeutic effects of the NEURVESTA treatment. This personalized closed-loop approach is expected to reduce the number of treatment sessions required to attain maximum balance recovery, which will lower treatment delivery costs and improve patient accessibility and adherence to NEURVESTA balance treatments.
Outcomes:
- Poster Presentation: a2 National Symposium 2025Title: Machine Learning-powered Wearables for Adaptive Electrical Vestibular Stimulation Balance Therapy for Older Adults at Home Authors: Abdul Aziz, Patrick Do, Tanvi Kandepuneni, Josh M Roper, Sameer Dhamne, John D Ralston, Deepak Ganesan, VP Nguyen
- Oral Presentation: MIT Club of Northern California – AI in Healthcare at the JP Morgan Healthcare ConferenceJohn Ralston presented on the NEURVESTA device mentioning the MassAITC pilot project work on January 14, 2025 as an featured AI startup at the AI Healthcare Event in association with the JP Morgan Healthcare Conference. Source: Event Post on MIT Club of Northern California Website
- Award: AgeTech Collaborative™ from AARP – AgeTech After Dark: Aging Made Easier Pitch Event Grand Prize WinnerJohn Ralston and the Neursantys team won the Grand Prize at the AgeTech After Dark pitch competition held in San Francisco on June 11, 2024. Source: @AgeTechCollab X.com Post – June 12, 2024