Developing real-world digital biomarkers from wearable sensors in Alzheimer’s disease

Jen Blankenship, VivoSense Inc. Michael Busa, UMass Amherst. The aim of this project is to develop and validate algorithms to capture measures of real-world walking behavior in patients with Alzheimer’s disease (AD). This project will provide critical validation evidence to support regulatory decision making.

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Testing a vocal biomarker platform for remote detection and monitoring of cognitive impairment in the home environment

Erik Larsen, Sonde Health. Brad Dickerson, Massachusetts General Hospital. Bonnie Wong, Massachusetts General Hospital. This project enrolls 50 subjects, age 55 and above, to participate in a longitudinal pilot study examining the potential to monitor mental status as a way to detect potential declines in cognitive functioning through a voice analysis (vocal biomarker) platform implemented on an existing smartphone app. The focus of this study is on feasibility in naturalistic environments (home) vs. controlled laboratory setting.

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