Patent: Patent Application Submitted
A Provisional Patent was filed on 8/3/23 at the US Patent Office.
A Provisional Patent was filed on 8/3/23 at the US Patent Office.
Authors: Yinan Xuan, Ava J. Fascetti, Colin Barry, Edward J. Wang Abstract BPClip is an ultra-low-cost cuffless blood pressure monitor. As a universal smartphone attachment, BPClip leverages the computational imaging power of smartphones to perform oscillometry based blood pressure measurements. This paper examines different design considerations in BPClip's development. The cost and accuracy of blood pressure measurements are the central design goals. Both of these requirements are achieved with the initial prototype that achieves a $0.80 USD material cost and a mean absolute error of 8.72 and 5.49 mmHg for systolic and diastolic blood pressure, respectively. Since a main motivator to develop BPClip is making blood pressure monitoring more accessible, usability is also central to the design. User studies were conducted throughout the design process to inform the most intuitive and accessible design features. In…
Authors: Shelby L. Bachman, Jennifer M. Blankenship, Michael Busa, Corinna Serviente, Kate Lyden, and Ieuan Clay Abstract Alzheimer's disease (AD) is a devastating neurodegenerative disease and the primary cause of dementia worldwide. Despite the magnitude of AD's impact on patients, caregivers, and society, nearly all AD clinical trials fail. A potential contributor to this high rate of failure is that established clinical outcome assessments fail to capture subtle clinical changes, entail high burden for patients and their caregivers, and ineffectively address the aspects of health deemed important by patients and their caregivers. AD progression is associated with widespread changes in physical behavior that have impacts on the ability to function independently, which is a meaningful aspect of health for patients with AD and important for diagnosis. However, established assessments of functional independence remain underutilized in…
Authors: Yinan Xuan, Colin Barry, Jessica De Souza, Jessica H Wen, Nick Antipa, Alison A Moore, Edward J Wang Abstract We propose an ultra-low-cost at-home blood pressure monitor that leverages a plastic clip with a spring-loaded mechanism to enable a smartphone with a flash LED and camera to measure blood pressure. Our system, called BPClip, is based on the scientific premise of measuring oscillometry at the fingertip to measure blood pressure. To enable a smartphone to measure the pressure applied to the digital artery, a moveable pinhole projection moves closer to the camera as the user presses down on the clip with increased force. As a user presses on the device with increased force, the spring-loaded mechanism compresses. The size of the pinhole thus encodes the pressure applied to the finger. In conjunction, the brightness…
Cambridge, Massachusetts--(Newsfile Corp. - May 12, 2023) - Today, MindMics, Inc. is pleased to announce it has launched its limited edition MindMics Heart Health System. The system uses patented and clinically validated sound-based technology known as In-ear Infrasonic HemodynographyTM (IH), embedded in everyday earbuds, to detect heart rate (HR) and heart rate variability (HRV) in real-time, and guides the user through breathing exercises to control their heart and master stress. By using sound to measure key biometrics, MindMics overcomes the challenges faced by wearables that use photoplethysmography (PPG) light technology. Factors like skin tone, skin thickness, perspiration and body mass can severely impact the accuracy of PPG readings. With MindMics, key organs like the heart are monitored through low-frequency acoustical vibrations detected in the ear canal. MindMics' IH delivers HR and HRV in real-time with a…
Title: Developing Real-World Digital Biomarkers from Wearable Sensors in Patients with Alzheimer's Disease Authors: Jen Blankenship, Shelby Bachman, Michael Busa, Corinna Serviente, Marzi Maja, Ieuan Clay, Kate Lyden
Title: Sensor-Guided Pharmacology in Alzheimer's Disease Authors: Ipsit Vahia, Rachel Sava, Rebecca Dickinson, Hailey Cray, Julia Kimball