Pilot B6 – Basu

Grant Funding: Novel orthostatic vital signs measured by an earlobe wearable device (1R21AG088945)

Principal investigator, Amar Basu, professor of electrical and computer engineering at Wayne State University and CEO of TRACE Biometrics LLC, has received a National Institute on Aging R21 award to further validate the TRACE sensor against gold standard clinical orthostatic measures, which will build upon the pilot award's work towards securing FDA clearance. Project Summary: Orthostatic disorders, including orthostatic hypotension (OH), disproportionately affect older adults, presenting in 30% of older adults and up to 70% of nursing home residents. As OH is a major risk factor for syncope, falls, and cognitive decline, medical agencies stress the public health need for monitoring orthostatic vital signs (OVS) in at-risk individuals. This proposal investigates an NIA award-winning wearable device called TRACE, which addresses fundamental limitations of the current clinical standard, the blood pressure (BP) cuff: 1) The BP…

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Publication: Predicting Orthostatic Symptoms Using a Multiparameter Wearable Sensor

Authors: Ziad A Elhajjaji, Amar S Basu Abstract Orthostatic disorders affect 30% of older adults and increase the risk for falls. The current diagnostic standard, the blood pressure cuff, cannot capture the rapid, multifaceted dynamics of orthostasis physiology, resulting in frequent underdiagnosis. This paper demonstrates multiparameter, real-time measurement of orthostasis using TRACE, an earlobe mounted wearable developed in our group. In prior work, we demonstrated a novel metric called orthostatic hypovolemia (OHV1), the initial loss in cephalic (head) blood volume immediately upon standing. This study significantly advances our prior work by introducing an additional 2 metrics: OHV2, the cephalic blood volume deficit after the body achieves homeostasis after standing; and postural orthostatic tachycardia (POT), the increase in heart rate. The 3 metrics were evaluated in 101 older adults who wore the TRACE device during postural…

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Company Launch: Trace Biometrics

About TRACE Biometrics was formed to commercialize their wearable OVS Platform. TRACE Biometrics provides a remote patient monitoring solution that empowers clinicians and caregivers to better manage orthostatic hypotension, a condition that affects 1 in 3 older adults and poses a significant risk for fall-related injuries. Their patented wearable device offers 6 categories of biometrics, providing unprecedented insights into patient health. Their goal is to harness next-generation remote monitoring to elevate patient outcomes and drive down healthcare costs. Website: https://www.linkedin.com/company/trace-biometrics?trk=public_profile_topcard-current-company ; https://www.trace.bio

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Publication: Assessing Novel Orthostatic Vital Signs with a Wearable Sensor

Authors: Ziad A. Elhajjaji, Amar S. Basu Abstract Orthostatic hypotension (OH) is a reduction in blood pressure and cerebral blood flow upon standing. Presenting in nearly 30% of older adults, OH is associated with increased fall risk and other co-morbidities. The clinical standard for monitoring OH, a blood pressure (BP) cuff, fails to capture initial orthostatic hypotension (IOH) and rapid hemodynamic changes during orthostasis. In contrast, cerebral blood flow velocity (CBFV) and continuous BP requires costly instrumentation unsuitable for home monitoring. As result OH is often underdiagnosed and poorly managed. This paper proposes a novel method for monitoring OH using TRACE, a wireless earlobe sensor that quantifies orthostatic hypovolemia (OHV), postural orthostatic tachycardia (POT), and motion during a standup test. To our knowledge, OHV is a novel biometric that may be correlated with dizziness upon…

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