Grant Funding: R01 AG082354
Title: Genomics-guided sleep biomarker discovery for early Alzheimer's disease: A wearables study This R01 builds upon the technology and algorithms for sleep-based metrics developed in the MassAITC pilot project, utilizing the same EEG device. It shifts the study from a general AD-risk factor population to a genetic AD-risk factor population. Public Health Relevance Statement: Sleep-based metrics are promising as potential noninvasive biomarkers for the early identification of individuals at risk of Alzheimer’s disease. In this R01 Research Project Grant, we will collect and analyze sleep and activity data from three wearable devices for sleep, heart rate, and activity monitoring along with blood biomarkers for Alzheimer’s disease from elderly Mass General Brigham Biobank participants with elevated genetic susceptibility to Alzheimer’s disease. We will also develop artificial intelligence tools for digital phenotyping and the discovery of novel…