Title: Neural mechanisms of gait disturbances as individualized digital biomarker trajectories in preclinical dementia
Public Health Relevance Statement: In this project, the research team uncovers the neural mechanisms of gait and mobility disturbances in preclinical dementia and identifies trackable individualized digital biomarkers (from videos). They evaluate the specificity and sensitivity of these gait-based biomarkers and relate those to neural mechanisms and clinical phenotypes. By leveraging these identified markers, they can monitor the disease’s progression, potentially minimizing or even replacing the demand for expensive neuropsychological or neuroimaging evaluations.
Source: R01AG089169 (NIH RePORTER)