Year 4 Pilots

Poster Presentation: 2026 Alzheimer’s Association International Conference

Title: Digital signatures of Alzheimer’s disease risk among Hispanic/Latino adults in the United States, showing how passive smartphone and wearable data can capture real-world behavioral markers of cognitive and cardiovascular risk. Authors: Raeanne Moore, Andrea Mendez Colmenares, Emma Churchill, Tess Filip, Linda C. Gallo, Alexander P. Demos, Erin E. Sundermann, Douglas R. Galasko & Maria Marquine Title: Daily Cognitive Function in Dementia Assessed Using Smartphone-Based EMA: Links with Dyadic Sleep Authors: Yeonsu Song, Laura Campbell, Brent Mausbach, Jennifer L. Martin, Mary-Lynn Brecht, Raeanne Moore Title: Day-to-day Memory Fluctuations in MCI: Linking Subjective Concerns to Real-World Performance Using Mobile Cognitive Assessment Authors: Laura M. Campbell, Emma Parrish, Colin A. Depp, Robert Ackerman, Philip D. Harvey, Amy E. Pinkham, Raeanne C. Moore

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Oral Presentation: Best Practices for Digital Phenotyping Research in Aging Populations

This is part of the monthly MassAITC webinar series. Abstract: Digital phenotyping is transforming aging research by enabling high-frequency, real-world measurement of cognition, behavior, symptoms, and context through smartphones, wearables, and passive sensing technologies. This talk will review how digital health tools can complement traditional clinic-based assessments by capturing intraindividual variability, diurnal patterns, environmental influences, and subtle changes in cognitive and functional performance that may signal risk for neurodegenerative disease. Using examples from studies of healthy aging, MCI, Alzheimer’s disease risk, dementia caregiving, and related clinical populations, the talk will highlight best practices for designing digital phenotyping protocols, balancing participant burden with data richness, maximizing adherence, integrating active cognitive assessments with passive data streams and biomarkers, and applying analytic approaches that distinguish within-person change from between-person differences. The session will emphasize opportunities for digital phenotyping…

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Oral Presentation: Developing Agentic AI Chatbot Tools with Older Adults and Caregivers to Encourage Participation in ADRD Clinical Trials

This is part of the monthly MassAITC webinar series. Abstract: Hype around the potential of generative AI tools to transform healthcare is at an all time high, but their design and utility is often not user or patient-centered. This is particularly true for generalized large language models that have limited UI/UX features, may hallucinate or give incorrect medical/healthcare advice, or may lack conversational clarity and specificity. In fact, these tools are rarely designed in partnership with the end-user or patients they intend to serve. As part of a2 Collective Pilot award in partnership with MassAITC, S-3 Research and California State Fullerton have been developing “TRIALCHAT”, a multiagentic AI tool with the goal of navigating older adults and their caregivers to resources related to Alzheimer’s Disease and clinical research participation opportunities. Lessons learned from a technology…

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